This introductory course is intended for students of organic and inorganic chemistry who intend to use NMR in their research.  The course provides the conceptual framework to understand and utilize modern NMR experiments.  About 1/3 of course is focused on chemical shift, spin coupling and the relation between spectra and structure.  The remaining 2/3 is an introduction to the principles and techniques of NMR.


  • High-Resolution NMR Techniques in Organic Chemistry, Claridge, Timothy D. W., Pergamon, ISBN-13: 978-0080999869, 3rd edition, 2016
  • NMR Data Interpretation Explained, Neil Jacobsen,  ISBN-13 9781118370223, Wiley, 2017.

Course syllabus

Class 1: Introduction to NMR, chemical shift and relation to structure, first order spectra

Class 2, 3: Spin coupling, complex first order spectra, Karplus relationship, magnetic and chemical equivalence,  Pople notation, second order spectra.

Class 4: Survey of info provided by 2D NMR Methods: COSY, DQF-COSY, ROESY, NOESY, HMQC, HMBC, TOCSY, etc….

Class 5,6:: Basic NMR theory: Vector and energy level diagram pictures of NMR, pulses, precession, and detection in terms of the vector diagram and FID, T1 and T2 relaxation, relation between relaxation and molecular structure and dynamics, spin echoes, diffusion measurements, decoupling,

Class 7,8: NOE theory and Applications

Class 9: Factors Affecting Sensitivity

Class 10,11: Instrumental aspects:   principles of shimming and resolution, FIDs and FT,  spectral windows and offsets, digitization and aliasing, digital resolution, dynamic range, window functions, overview of instrumental hardware.

Class 12: Chemical Exchange, Ligand Binding and STD experiment

Time Permitting: Experimental 2D NMR what is a 2D experiment? , Heteronuclear NMR, solid state NMR